| http://purl.uniprot.org/citations/32822073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32822073 | http://www.w3.org/2000/01/rdf-schema#comment | "The Envelope protein (E) is one of the four structural proteins encoded by the genome of SARS-CoV and SARS-CoV-2 Coronaviruses. It is an integral membrane protein, highly expressed in the host cell, which is known to have an important role in Coronaviruses maturation, assembly and virulence. The E protein presents a PDZ-binding motif at its C-terminus. One of the key interactors of the E protein in the intracellular environment is the PDZ containing protein PALS1. This interaction is known to play a key role in the SARS-CoV pathology and suspected to affect the integrity of the lung epithelia. In this paper we measured and compared the affinity of peptides mimicking the E protein from SARS-CoV and SARS-CoV-2 for the PDZ domain of PALS1, through equilibrium and kinetic binding experiments. Our results support the hypothesis that the increased virulence of SARS-CoV-2 compared to SARS-CoV may rely on the increased affinity of its Envelope protein for PALS1."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.org/dc/terms/identifier | "doi:10.1002/pro.3936"xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/author | "Gianni S."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/author | "Stromgaard K."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/author | "Pagano L."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/author | "Visconti L."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/author | "Toto A."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/author | "Malagrino F."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/name | "Protein Sci"xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/pages | "2038-2042"xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/title | "Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein."xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/32822073 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32822073 |
| http://purl.uniprot.org/citations/32822073 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32822073 |
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