| http://purl.uniprot.org/citations/32823233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32823233 | http://www.w3.org/2000/01/rdf-schema#comment | "Ovarian cancer is the most lethal gynecological malignancy worldwide. A better understanding of the pathogenesis of ovarian cancer may help to improve the overall survival. Our previous studies have demonstrated that alpha-(1,2)-fucosyltransferase 1 (FUT1) is an oncogenic glycogene in ovarian cancer. However, the underlying mechanism is not fully clarified. In this study, we identified a microRNA as an important downstream regulator for the carcinogenic effect of FUT1 in ovarian cancer. miR-5193 was found down-regulated in ovarian cancer cells, FUT1-overexpression ovarian cancer cells and ovarian tumor samples. MTT, flow cytometry and Transwell assays demonstrated that miR-5193 inhibited the proliferation and migration, and induced the cell cycle arrest and apoptosis of ovarian cancer cells. Real-time PCR and western blot assays showed that miR-5193 downregulated the expression of TRIM11 and upregulated the expression of p53 and p21. Dual luciferase reporter assay indicated that TRIM11 was a direct target of miR‑5193. Rescue experiments confirmed that miR-5193 functioned in ovarian cancer cells by directly targeting TRIM11. Moreover, transfection with miR-5193 mimic in FUT1-overexpression ovarian cancer cells reversed the carcinogenic effect of FUT1. Taken together, our results suggest that miR-5193 is an essential suppressor of human ovarian cancer development, and is an important downstream regulator regarding the carcinogenesis of FUT1 in ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.prp.2020.153148"xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Gao L."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Liu D."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Song Z."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Lin B."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/author | "Guo Q."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/name | "Pathol Res Pract"xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/pages | "153148"xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/title | "miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11."xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://purl.uniprot.org/core/volume | "216"xsd:string |
| http://purl.uniprot.org/citations/32823233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32823233 |
| http://purl.uniprot.org/citations/32823233 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32823233 |
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| http://purl.uniprot.org/uniprot/#_A0A0A0QYD1-mappedCitation-32823233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32823233 |
| http://purl.uniprot.org/uniprot/#_A0A0A0R222-mappedCitation-32823233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32823233 |
| http://purl.uniprot.org/uniprot/#_A0A165G1H9-mappedCitation-32823233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32823233 |
| http://purl.uniprot.org/uniprot/#_A7XM28-mappedCitation-32823233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32823233 |