| http://purl.uniprot.org/citations/32846120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32846120 | http://www.w3.org/2000/01/rdf-schema#comment | "Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key driver of acute lung injury during bacterial pneumonia. Here, we evaluate the impact of IAV on PFT-induced acute lung injury during co- and secondary Streptococcus pneumoniae (Spn) infection. We observe that IAV synergistically sensitizes lung epithelial cells for PFT-mediated necroptosis in vitro and in murine models of Spn co-infection and secondary infection. Pharmacoelogical induction of oxidative stress without virus sensitizes cells for PFT-mediated necroptosis. Antioxidant treatment or inhibition of necroptosis reduces disease severity during secondary bacterial infection. Our results advance our understanding on the molecular basis of co- and secondary bacterial infection to influenza and identify necroptosis inhibition and antioxidant therapy as potential intervention strategies."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.108062"xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Jureka A.S."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Orihuela C.J."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Dube P.H."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Gilley R.P."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Petit C.M."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Harrod K.S."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Brand J.D."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Platt M.P."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Scott N.R."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Gonzalez-Juarbe N."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Trombley J.E."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/author | "Riegler A.N."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/pages | "108062"xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/title | "Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis."xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/32846120 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32846120 |
| http://purl.uniprot.org/citations/32846120 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32846120 |
| http://purl.uniprot.org/uniprot/#_D3YV42-mappedCitation-32846120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32846120 |
| http://purl.uniprot.org/uniprot/#_Q9D2Y4-mappedCitation-32846120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32846120 |
| http://purl.uniprot.org/uniprot/D3YV42 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32846120 |