| http://purl.uniprot.org/citations/32851185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32851185 | http://www.w3.org/2000/01/rdf-schema#comment | "4E-BP (eIF4E-BP) represses translation initiation by binding to the 5' cap-binding protein eIF4E and inhibiting its activity. Although 4E-BP has been shown to be important in growth control, stress response, cancer, neuronal activity, and mammalian circadian rhythms, it is not understood how it preferentially represses a subset of mRNAs. We successfully used HyperTRIBE (targets of RNA binding proteins identified by editing) to identify in vivo 4E-BP mRNA targets in both Drosophila and mammals under conditions known to activate 4E-BP. The protein associates with specific mRNAs, and ribosome profiling data show that mTOR inhibition changes the translational efficiency of 4E-BP TRIBE targets more substantially compared to nontargets. In both systems, these targets have specific motifs and are enriched in translation-related pathways, which correlate well with the known activity of 4E-BP and suggest that it modulates the binding specificity of eIF4E and contributes to mTOR translational specificity."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abb8771"xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Jin H."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Rahman R."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Rosbash M."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Na D."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/author | "Fieldsend A."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/pages | "eabb8771"xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/title | "TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals."xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/32851185 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32851185 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4K6N1-mappedCitation-32851185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32851185 |