| http://purl.uniprot.org/citations/3285180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3285180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3285180 | http://www.w3.org/2000/01/rdf-schema#comment | "The Saccharomyces cerevisiae pheromone a-factor is produced by a cells and interacts with alpha cells to cause cell cycle arrest and other physiological responses associated with mating. Two a-factor structural genes, MFA1 and MFA2, have been previously cloned with synthetic probes based on the a-factor amino acid sequence (A. Brake, C. Brenner, R. Najarian, P. Laybourn, and J. Merryweather, cited in M.-J. Gething [ed.], Protein transport and secretion, 1985). We have examined the function of these genes in a-factor production and mating by construction and analysis of chromosomal null mutations. mfa1 and mfa2 single mutants each exhibited approximately half the wild-type level of a-factor activity and were proficient in mating, whereas the mfa1 mfa2 double mutant produced no a-factor and was unable to mate. These results demonstrate that both genes are functional, that each gene makes an equivalent contribution to the a-factor activity and mating capacity of a cells, and that a-factor plays an essential role in mating. Strikingly, exogenous a-factor did not alleviate the mating defect of the double mutant, suggesting that an a cell must be producing a-factor to be an effective mating partner."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.8.3.1309-1318.1988"xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.8.3.1309-1318.1988"xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/author | "Herskowitz I."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/author | "Herskowitz I."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/author | "Michaelis S."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/author | "Michaelis S."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/date | "1988"xsd:gYear |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/pages | "1309-1318"xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/pages | "1309-1318"xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/title | "The a-factor pheromone of Saccharomyces cerevisiae is essential for mating."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/title | "The a-factor pheromone of Saccharomyces cerevisiae is essential for mating."xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/3285180 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3285180 |
| http://purl.uniprot.org/citations/3285180 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3285180 |
| http://purl.uniprot.org/citations/3285180 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/3285180 |
| http://purl.uniprot.org/citations/3285180 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/3285180 |
| http://purl.uniprot.org/uniprot/P34166 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/3285180 |
| http://purl.uniprot.org/uniprot/P34165 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/3285180 |