http://purl.uniprot.org/citations/32862607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/32862607 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeMicroRNA-215 (miR-215) has been reported to show different effects in human cancers. However, the function of miR-215 remains unclear in nasopharyngeal carcinoma (NPC). Hence, this research was designed to investigate the effect of miR-215 on the development of NPC.MethodsThe expression levels of miR-215 and RB1 were examined in NPC via the qRT-PCR assay. The protein expression was observed through immunocytochemical assay and western blot. MTT (methyl thiazolyl tetrazolium) and Transwell assays were employed to explore the effect of miR-215. The relationship between miR-215 and retinoblastoma (RB)1 was assessed by dual luciferase assay.ResultsUpregulation of miR-215 was identified in NPC tissues and predicted worse prognosis of NPC. Cell proliferation, migration and invasion were promoted by overexpression of miR-215 in NPC. Furthermore, miR-215 directly targeted RB1 which was downregulated in NPC. MiR-215 promoted the progression of NPC through targeting RB1. In particular, miR-215 promoted EMT (epithelial-mesenchymal transition) and activated Wnt/β-catenin pathway in NPC.ConclusionMiR-215 promoted the development of NPC through suppressing RB1 and activating Wnt/β-catenin pathway."xsd:string |
http://purl.uniprot.org/citations/32862607 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
http://purl.uniprot.org/citations/32862607 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
http://purl.uniprot.org/citations/32862607 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
http://purl.uniprot.org/citations/32862607 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
http://purl.uniprot.org/citations/32862607 | http://purl.uniprot.org/core/name | "J BUON"xsd:string |
http://purl.uniprot.org/citations/32862607 | http://purl.uniprot.org/core/pages | "1579-1586"xsd:string |
http://purl.uniprot.org/citations/32862607 | http://purl.uniprot.org/core/title | "MicroRNA-215 promoted the progression of nasopharyngeal carcinoma through targeting RB1 and activating Wnt/beta-catenin pathway."xsd:string |
http://purl.uniprot.org/citations/32862607 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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