| http://purl.uniprot.org/citations/32877917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32877917 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein product of the cyclin D1 oncogene functions by activating partner cyclin-dependent kinases (cdk)4 or cdk6 to phosphorylate, thereby inactivating, the retinoblastoma protein pRB. Nonclassical, cdk-independent, functions of cyclin D1 have been described but their role in cyclin D1-driven neoplasia, with attendant implications for recently approved cdk4/6 chemotherapeutic inhibitors, requires further examination. We investigated whether cyclin D1's role in parathyroid tumorigenesis in vivo is effected primarily through kinase-dependent or kinase-independent mechanisms. Using a mouse model of cyclin D1-driven parathyroid tumorigenesis (PTH-D1), we generated new transgenic lines harboring a mutant cyclin D1 (KE) that is unable to activate its partner kinases. While this kinase-dead KE mutant effectively drove mammary tumorigenesis in an analogous model, parathyroid-overexpressed cyclin D1 KE mice did not develop the characteristic biochemical hyperparathyroidism or parathyroid hypercellularity of PTH-D1 mice. These results strongly suggest that in parathyroid cells, cyclin D1 drives tumorigenesis predominantly through cdk-dependent mechanisms, in marked contrast with the cdk-independence of cyclin D1-driven mouse mammary cancer. These findings highlight crucial tissue-specific mechanistic differences in cyclin D1-driven tumorigenesis, suggest that parathyroid/endocrine cells may be more tumorigenically vulnerable to acquired genetic perturbations in cdk-mediated proliferative control than other tissues, and carry important considerations for therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.org/dc/terms/identifier | "doi:10.1210/endocr/bqaa159"xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Rose M."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Shah S."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Arnold A."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Corrado K."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Romano R."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Bellizzi J."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Alander C."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Mallya S."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Costa-Guda J."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Saucier K."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/author | "Saria E."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/pages | "bqaa159"xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/title | "CDK4/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice."xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/32877917 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32877917 |
| http://purl.uniprot.org/citations/32877917 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32877917 |
| http://purl.uniprot.org/uniprot/#_Q0VBK8-mappedCitation-32877917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32877917 |
| http://purl.uniprot.org/uniprot/#_B2M0W7-mappedCitation-32877917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32877917 |
| http://purl.uniprot.org/uniprot/#_P25322-mappedCitation-32877917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32877917 |
| http://purl.uniprot.org/uniprot/#_Q64261-mappedCitation-32877917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32877917 |