| http://purl.uniprot.org/citations/32878909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32878909 | http://www.w3.org/2000/01/rdf-schema#comment | "Germinal centers (GCs) are a structure in which B cell populations are clonally expanded, depending on their affinities to Ag. Although we previously isolated a characteristic protein called dedicator of cytokinesis 11 (DOCK11) from GC B cells, limited information is available on the roles of DOCK11 in GC B cells. In this study, we demonstrate that DOCK11 may contribute to the expansion of Ag-specific populations among GC B cells upon immunization of mice. The lack of DOCK11 in B cells resulted in the lower frequency of Ag-specific GC B cells along with enhanced apoptosis upon immunization. Under competitive conditions, DOCK11-deficient B cells were dramatically prevented from participating in GCs, in contrast to DOCK11-sufficient B cells. However, minor impacts of the DOCK11 deficiency were identified on somatic hypermutations. Mechanistically, the DOCK11 deficiency resulted in the suppression of B cell-intrinsic signaling in vitro and in vivo. Although DOCK11 expression by B cells was required for the induction of T follicular helper cells at the early stages of immune responses, minor impacts were identified on the expansion of Ag-specific populations among GC B cells. Thus, DOCK11 appears to contribute to the expansion of Ag-specific populations among GC B cells through the stimulation of B cell-intrinsic signaling."xsd:string |
| http://purl.uniprot.org/citations/32878909 | http://purl.org/dc/terms/identifier | "doi:10.4049/immunohorizons.2000048"xsd:string |
| http://purl.uniprot.org/citations/32878909 | http://purl.uniprot.org/core/author | "Sakamoto A."xsd:string |
| http://purl.uniprot.org/citations/32878909 | http://purl.uniprot.org/core/author | "Maruyama M."xsd:string |
| http://purl.uniprot.org/citations/32878909 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32878909 | http://purl.uniprot.org/core/name | "Immunohorizons"xsd:string |
| http://purl.uniprot.org/citations/32878909 | http://purl.uniprot.org/core/pages | "520-529"xsd:string |
| http://purl.uniprot.org/citations/32878909 | http://purl.uniprot.org/core/title | "Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells."xsd:string |
| http://purl.uniprot.org/citations/32878909 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/32878909 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32878909 |
| http://purl.uniprot.org/citations/32878909 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32878909 |
| http://purl.uniprot.org/uniprot/#_A0A2X0U2I4-mappedCitation-32878909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878909 |
| http://purl.uniprot.org/uniprot/#_A2AF47-mappedCitation-32878909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878909 |
| http://purl.uniprot.org/uniprot/#_Q8CCF4-mappedCitation-32878909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878909 |
| http://purl.uniprot.org/uniprot/Q8CCF4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32878909 |
| http://purl.uniprot.org/uniprot/A0A2X0U2I4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32878909 |
| http://purl.uniprot.org/uniprot/A2AF47 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32878909 |