| http://purl.uniprot.org/citations/32878923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32878923 | http://www.w3.org/2000/01/rdf-schema#comment | "Multipotent retinal progenitor cells (RPCs) generate various cell types in a precise chronological order, but how exactly cone photoreceptor production is restricted to early stages remains unclear. Here, we show that the POU-homeodomain factors Pou2f1/Pou2f2, the homologs of Drosophila temporal identity factors nub/pdm2, regulate the timely production of cones in mice. Forcing sustained expression of Pou2f1 or Pou2f2 in RPCs expands the period of cone production, whereas misexpression in late-stage RPCs triggers ectopic cone production at the expense of late-born fates. Mechanistically, we report that Pou2f1 induces Pou2f2 expression, which binds to a POU motif in the promoter of the rod-inducing factor Nrl to repress its expression. Conversely, conditional inactivation of Pou2f2 in RPCs increases Nrl expression and reduces cone production. Finally, we provide evidence that Pou2f1 is part of a cross-regulatory cascade with the other temporal identity factors Ikzf1 and Casz1. These results uncover Pou2f1/2 as regulators of the temporal window for cone genesis and, given their widespread expression in the nervous system, raise the possibility of a general role in temporal patterning.This article has an associated 'The people behind the papers' interview."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.188730"xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Lu S."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Javed A."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Cayouette M."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Kloc M."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Bremner R."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Ali R.R."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Gonzalez-Cordero A."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Mattar P."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/author | "Kruczek K."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/pages | "dev188730"xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/title | "Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina."xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/32878923 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32878923 |
| http://purl.uniprot.org/citations/32878923 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32878923 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWN1-mappedCitation-32878923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878923 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXW9-mappedCitation-32878923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878923 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY14-mappedCitation-32878923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878923 |
| http://purl.uniprot.org/uniprot/#_A0A087WNK8-mappedCitation-32878923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878923 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQA9-mappedCitation-32878923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878923 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQE0-mappedCitation-32878923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32878923 |