| http://purl.uniprot.org/citations/32880660 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32880660 | http://www.w3.org/2000/01/rdf-schema#comment | "Remodeling of the intracellular cytoskeleton plays a key role in accelerating tumor growth and metastasis. Targeting different cytoskeletal elements is important for existing and future anticancer therapies. Anillin is a unique scaffolding protein that interacts with major cytoskeletal structures, e.g., actin filaments, microtubules and septin polymers. A well-studied function of this scaffolding protein is the regulation of cytokinesis at the completion of cell division. Emerging evidence suggest that anillin has other important activities in non-dividing cells, including control of intercellular adhesions and cell motility. Anillin is markedly overexpressed in different solid cancers and its high expression is commonly associated with poor prognosis of patient survival. This review article summarizes rapidly accumulating evidence that implicates anillin in the regulation of tumor growth and metastasis. We focus on molecular and cellular mechanisms of anillin-dependent tumorigenesis that include both canonical control of cytokinesis and novel poorly understood functions as a nuclear regulator of the transcriptional reprogramming and phenotypic plasticity of cancer cells."xsd:string |
| http://purl.uniprot.org/citations/32880660 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-020-03605-9"xsd:string |
| http://purl.uniprot.org/citations/32880660 | http://purl.uniprot.org/core/author | "Ivanov A.I."xsd:string |
| http://purl.uniprot.org/citations/32880660 | http://purl.uniprot.org/core/author | "Koblinski J.E."xsd:string |
| http://purl.uniprot.org/citations/32880660 | http://purl.uniprot.org/core/author | "Naydenov N.G."xsd:string |
| http://purl.uniprot.org/citations/32880660 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32880660 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/32880660 | http://purl.uniprot.org/core/pages | "621-633"xsd:string |
| http://purl.uniprot.org/citations/32880660 | http://purl.uniprot.org/core/title | "Anillin is an emerging regulator of tumorigenesis, acting as a cortical cytoskeletal scaffold and a nuclear modulator of cancer cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/32880660 | http://purl.uniprot.org/core/volume | "78"xsd:string |
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