| http://purl.uniprot.org/citations/32889153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32889153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32889153 | http://www.w3.org/2000/01/rdf-schema#comment | "Human basophils regulate allergic reactions by secreting histamine, interleukin 4 (IL-4) and IL-13 through key surface receptors FcεRI as well as IL-3R, which are constitutively expressed on basophils. IL-3/IL-3R signaling axis plays key roles in regulating the development and activation of basophils. We and others have shown that IL-3-induced surface receptors e.g. ST2, IL-17RB and IL-2 receptors regulate the biology of basophils. However, the expression and function of IL-3-induced surface proteins on human basophils remain to be elucidated. We in this study aimed to identify new basophil activation regulators by transcriptomic analysis of IL-3-stimulated basophils. Gene expression microarray analysis of IL-3-treated basophils revealed 2050 differentially expressed genes, of which 323 genes encoded surface proteins including GITR. We identified that GITR was preferentially induced by IL-3 rather than anti-IgE, IL-33, fMLP and C5a. IL-3-induced GITR was suppressed by inhibitors targeting JAK2, PI3K and MEK1/2. Stimulation of IL-3-treated basophils by GITR enhanced the expression of IL-4 and IL-13. Moreover, IgE-mediated degranulation was enhanced by GITRL in the presence of IL-3. This transcriptomic analysis of IL-3-activated basophils helps to identify novel activation regulator. IL-3-induced GITR promoted the activation of basophils, adding new evidence supporting GITR as an important player in Th2-associated immune responses."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2020.155268"xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2020.155268"xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "He C."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "He C."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Hong L."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Hong L."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Gao S."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Gao S."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Pan S."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Pan S."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Shi Z."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Shi Z."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/32889153 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |