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http://purl.uniprot.org/citations/32892475http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32892475http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Flares of lupus nephritis (LN) are frequent and associated with impaired renal prognosis. One major management obstacle in LN flare is the lack of effective methods to identify at-risk patients earlier in their disease course. This study was undertaken to test the utility of measurement of urinary matrix metalloproteinase 7 (MMP-7) for the dynamic surveillance of renal disease activity and prediction of renal flares in LN.

Methods

A prospective, 2-stage cohort study was performed in patients with LN. Urinary MMP-7 levels at the time of biopsy were evaluated in 154 patients with newly diagnosed LN in 2 independent cohorts. Urinary MMP-7 levels were assessed for correlation with renal histologic activity. Furthermore, after a minimum period of 12 months of renal disease remission, urinary MMP-7 levels were monitored bimonthly for 2 years in 65 patients with LN. The association between urinary MMP-7 levels and development of LN flare was analyzed.

Results

Urinary MMP-7 levels were elevated in patients with LN. A higher urinary MMP-7 level in LN was associated with greater renal histologic activity. As a marker for identifying LN patients with more severe renal histologic activity (i.e., a histologic activity index of ≥7), the level of urinary MMP-7 outperformed other clinical markers and improved their predictive performance, thus linking urinary MMP-7 levels to renal disease activity. Furthermore, among patients who had follow-up measurements of urinary MMP-7 after achievement of long-term remission of renal disease activity, an elevated urinary MMP-7 level during follow-up was independently associated with an increased risk of LN flare. This elevation in the urinary MMP-7 level hinted at the risk of an LN flare at an earlier time point prior to indications using conventional laboratory measures. Thus, use of the urinary MMP-7 level in conjunction with other clinical measures improved the prognostic value for prediction of an LN flare.

Conclusion

Urinary MMP-7 levels in LN are correlated with renal histologic activity. An elevated urinary MMP-7 level detected after achievement of long-term renal disease remission is associated with a higher risk of incident renal flare in patients with LN."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.org/dc/terms/identifier"doi:10.1002/art.41506"xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Feng X."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Jin L."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Wang G."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Zhou Z."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Shi M."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Yang M."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Wu L."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Yang B."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Su H."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Cao W."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/author"Su C."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/name"Arthritis Rheumatol"xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/pages"265-275"xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/title"Association of Urinary Matrix Metalloproteinase 7 Levels With Incident Renal Flare in Lupus Nephritis."xsd:string
http://purl.uniprot.org/citations/32892475http://purl.uniprot.org/core/volume"73"xsd:string
http://purl.uniprot.org/citations/32892475http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32892475
http://purl.uniprot.org/citations/32892475http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32892475
http://purl.uniprot.org/uniprot/#_A5GZ72-mappedCitation-32892475http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32892475
http://purl.uniprot.org/uniprot/#_B4DDW4-mappedCitation-32892475http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32892475
http://purl.uniprot.org/uniprot/#_Q53GF1-mappedCitation-32892475http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32892475
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