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http://purl.uniprot.org/citations/3290053http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3290053http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3290053http://www.w3.org/2000/01/rdf-schema#comment"We report the isolation and nucleotide sequence determination of a beta-tubulin gene (TUB2) from the pathogenic dimorphic fungus Candida albicans. Nucleotide sequence analysis revealed that TUB2 encodes a protein of 449 amino acids (aa) with considerable sequence homology to beta-tubulins isolated from other fungal species. The nucleotide sequence of the C. albicans gene is 70% homologous to that of the Saccharomyces cerevisiae gene. The coding region for the C. albicans beta-tubulin gene is interrupted by two introns. The first intron occurs after the 4th aa and the second intron occurs after the 13th aa. A comparison with other fungal beta-tubulin genes indicates that the intron locations are highly conserved. Codon usage in the C. albicans TUB2 gene is nonrandom, as has been observed for other fungal beta-tubulin genes. The C. albicans TUB2 gene is transcribed to yield a 1.8-kb mRNA species. On the basis of genomic Southern-blot analysis, we conclude that C. albicans most likely possesses a single beta-tubulin gene."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.org/dc/terms/identifier"doi:10.1016/0378-1119(88)90545-8"xsd:string
http://purl.uniprot.org/citations/3290053http://purl.org/dc/terms/identifier"doi:10.1016/0378-1119(88)90545-8"xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Koltin Y."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Koltin Y."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Smith R.A."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Smith R.A."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Gorman J.A."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Gorman J.A."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Allaudeen H.S."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Allaudeen H.S."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Whitman M.H."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/author"Whitman M.H."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/date"1988"xsd:gYear
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/date"1988"xsd:gYear
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/name"Gene"xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/name"Gene"xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/pages"53-63"xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/pages"53-63"xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/title"Isolation and characterization of a beta-tubulin gene from Candida albicans."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/title"Isolation and characterization of a beta-tubulin gene from Candida albicans."xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/volume"63"xsd:string
http://purl.uniprot.org/citations/3290053http://purl.uniprot.org/core/volume"63"xsd:string