| http://purl.uniprot.org/citations/32911070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32911070 | http://www.w3.org/2000/01/rdf-schema#comment | "Hedgehog signaling plays a crucial role in embryogenesis and adult tissue homeostasis, and mutations of its key components such as Suppressor of fused (Sufu) are closely associated with human diseases. The Ser/Thr kinase Fused (Fu) promotes Hedgehog signaling by phosphorylating the Cubitus interruptus (Ci)/Glioma-associated oncogene homologue (Gli) family of transcription factors. Sufu associates with both Fu and Ci/Gli, but the recognition mechanism between Sufu and Fu remains obscure. Here, our structure of the N-terminal domain (NTD) of Drosophila Sufu (dSufu) in complex with the Sufu-binding site (SBS) of Fu reveals that both main-chain β sheet formation and side-chain hydrophobic interactions contribute to the recognition between Sufu and Fu, and point mutations of highly conserved interface residues eliminated their association. Structural comparison suggests that Fu and Ci/Gli bind on opposite sides of dSufu-NTD, allowing the formation of a Fu-dSufu-Ci ternary complex which facilitates the phosphorylation of Ci/Gli by Fu. Hence, our results provide insights into the Sufu-Fu recognition mechanism."xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jsb.2020.107614"xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/name | "J Struct Biol"xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/pages | "107614"xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/title | "Structural insight into the recognition between Sufu and fused in the Hedgehog signal transduction pathway."xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://purl.uniprot.org/core/volume | "212"xsd:string |
| http://purl.uniprot.org/citations/32911070 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32911070 |
| http://purl.uniprot.org/citations/32911070 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32911070 |
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| http://purl.uniprot.org/uniprot/#_H9XVL7-mappedCitation-32911070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32911070 |
| http://purl.uniprot.org/uniprot/#_Q27279-mappedCitation-32911070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32911070 |
| http://purl.uniprot.org/uniprot/#_P19538-mappedCitation-32911070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32911070 |
| http://purl.uniprot.org/uniprot/#_P23647-mappedCitation-32911070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32911070 |
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| http://purl.uniprot.org/uniprot/Q27279 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32911070 |
| http://purl.uniprot.org/uniprot/P23647 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32911070 |
| http://purl.uniprot.org/uniprot/H9XVL6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32911070 |
| http://purl.uniprot.org/uniprot/P19538 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32911070 |