| http://purl.uniprot.org/citations/32917241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32917241 | http://www.w3.org/2000/01/rdf-schema#comment | "Variants of the cytoplasmic FMR1-interacting protein (CYFIP) gene family, CYFIP1 and CYFIP2, are associated with numerous neurodevelopmental and neuropsychiatric disorders. According to several studies, CYFIP1 regulates the development and function of both pre- and post-synapses in neurons. Furthermore, various studies have evaluated CYFIP2 functions in the postsynaptic compartment, such as regulating dendritic spine morphology; however, no study has evaluated whether and how CYFIP2 affects presynaptic functions. To address this issue, in this study, we have focused on the presynapses of layer 5 neurons of the medial prefrontal cortex (mPFC) in adult Cyfip2 heterozygous (Cyfip2+/-) mice. Electrophysiological analyses revealed an enhancement in the presynaptic short-term plasticity induced by high-frequency stimuli in Cyfip2+/- neurons compared with wild-type neurons. Since presynaptic mitochondria play an important role in buffering presynaptic Ca2+, which is directly associated with the short-term plasticity, we analyzed presynaptic mitochondria using electron microscopic images of the mPFC. Compared with wild-type mice, the number, but not the volume or cristae density, of mitochondria in both presynaptic boutons and axonal processes in the mPFC layer 5 of Cyfip2+/- mice was reduced. Consistent with an identification of mitochondrial proteins in a previously established CYFIP2 interactome, CYFIP2 was detected in a biochemically enriched mitochondrial fraction of the mouse mPFC. Collectively, these results suggest roles for CYFIP2 in regulating presynaptic functions, which may involve presynaptic mitochondrial changes."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13041-020-00668-4"xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Kang H."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Han K."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Kim S.Y."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Lee K.J."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Choi S.Y."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Jin C."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Lee C.H."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Kwon S.K."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Kang H.R."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Ma R."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/author | "Kim G.H."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/name | "Mol Brain"xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/pages | "123"xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/title | "Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice."xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/32917241 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32917241 |
| http://purl.uniprot.org/citations/32917241 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32917241 |