| http://purl.uniprot.org/citations/32917889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32917889 | http://www.w3.org/2000/01/rdf-schema#comment | "Arterial macrophages have different developmental origins, but the association of macrophage ontogeny with their phenotypes and functions in adulthood is still unclear. Here, we combine macrophage fate-mapping analysis with single-cell RNA sequencing to establish their cellular identity during homeostasis, and in response to angiotensin-II (AngII)-induced arterial inflammation. Yolk sac erythro-myeloid progenitors (EMP) contribute substantially to adventitial macrophages and give rise to a defined cluster of resident immune cells with homeostatic functions that is stable in adult mice, but declines in numbers during ageing and is not replenished by bone marrow (BM)-derived macrophages. In response to AngII inflammation, increase in adventitial macrophages is driven by recruitment of BM monocytes, while EMP-derived macrophages proliferate locally and provide a distinct transcriptional response that is linked to tissue regeneration. Our findings thus contribute to the understanding of macrophage heterogeneity, and associate macrophage ontogeny with distinct functions in health and disease."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-18287-x"xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Fischer M."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Engelhardt S."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Molkentin J.D."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Perdiguero E.G."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Schulz C."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Schneider V."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Massberg S."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Waskow C."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Vagnozzi R.J."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Thaler R."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Busch K."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Stremmel C."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Klapproth K."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Weinberger T."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Ishikawa-Ankerhold H."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Messerer D."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Titova A."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Esfandyari D."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Klosges L."xsd:string |
| http://purl.uniprot.org/citations/32917889 | http://purl.uniprot.org/core/author | "Percin G."xsd:string |