| http://purl.uniprot.org/citations/32924161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32924161 | http://www.w3.org/2000/01/rdf-schema#comment | "Ultraviolet B (UVB) exposure is a core factor that leads to skin disease or carcinogenesis through the insufficient repair of DNA lesions. UVB-induced DNA lesions are mainly removed by the nucleotide excision repair (NER) mechanism. The expression of histone deacetylase 4 (HDAC4) is altered in the skin upon UVB exposure, indicating its possible implication in UVB-induced DNA lesions repair. Here, we investigated the role of HDAC4 in the NER removal of the main classes of UVB-induced DNA lesions consisting of cyclobutane pyrimidine dimers and pyrimidine (6-4) pyrimidone photoproducts (6-4PPs). We found that UVB irradiation increased HDAC4 expression at both the mRNA and protein levels. HDAC4 interacted with NER factor XPC, which played an important role in effectively removing the UVB-induced DNA lesions. This study provides an understanding of the HDAC4 function in DNA repair, which will allow the development of efficient strategies to protect the skin from UVR-induced diseases."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.org/dc/terms/identifier | "doi:10.1002/mc.23257"xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Jiao Y."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Li S.'"xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Cai H."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Hua L."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/author | "Ze K."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/name | "Mol Carcinog"xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/pages | "1292-1301"xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/title | "Protective role of histone deacetylase 4 from ultraviolet radiation-induced DNA lesions."xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/32924161 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32924161 |
| http://purl.uniprot.org/citations/32924161 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32924161 |
| http://purl.uniprot.org/uniprot/#_Q3TNU8-mappedCitation-32924161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32924161 |
| http://purl.uniprot.org/uniprot/#_Q6NZM9-mappedCitation-32924161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32924161 |