| http://purl.uniprot.org/citations/32931550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32931550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32931550 | http://www.w3.org/2000/01/rdf-schema#comment | "Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key role in synaptic plasticity. In the present study, we demonstrate across different metabolic stress conditions that modulate malonyl-CoA levels in cortical neurons that CPT1C regulates the trafficking of the major AMPAR subunit, GluA1, through the phosphatidyl-inositol-4-phosphate (PI(4)P) phosphatase SAC1. In normal conditions, CPT1C down-regulates SAC1 catalytic activity, allowing efficient GluA1 trafficking to the plasma membrane. However, under low malonyl-CoA levels, such as during glucose depletion, CPT1C-dependent inhibition of SAC1 is released, facilitating SAC1's translocation to ER-TGN contact sites to decrease TGN PI(4)P pools and trigger GluA1 retention at the TGN. Results reveal that GluA1 trafficking is regulated by CPT1C sensing of malonyl-CoA and provide the first report of a SAC1 inhibitor. Moreover, they shed light on how nutrients can affect synaptic function and cognition."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201912045"xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201912045"xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Chohnan S."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Chohnan S."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Dickson E.J."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Dickson E.J."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Casals N."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Casals N."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Fado R."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Fado R."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Sole M."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Sole M."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Casas M."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Casas M."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Dominguez J.L."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Dominguez J.L."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Kaku M."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Kaku M."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Minano-Molina A.J."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Minano-Molina A.J."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Rodriguez-Alvarez J."xsd:string |
| http://purl.uniprot.org/citations/32931550 | http://purl.uniprot.org/core/author | "Rodriguez-Alvarez J."xsd:string |