| http://purl.uniprot.org/citations/32937646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32937646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32937646 | http://www.w3.org/2000/01/rdf-schema#comment | "Viperin is an interferon-induced cellular protein that is conserved in animals1. It has previously been shown to inhibit the replication of multiple viruses by producing the ribonucleotide 3'-deoxy-3',4'-didehydro (ddh)-cytidine triphosphate (ddhCTP), which acts as a chain terminator for viral RNA polymerase2. Here we show that eukaryotic viperin originated from a clade of bacterial and archaeal proteins that protect against phage infection. Prokaryotic viperins produce a set of modified ribonucleotides that include ddhCTP, ddh-guanosine triphosphate (ddhGTP) and ddh-uridine triphosphate (ddhUTP). We further show that prokaryotic viperins protect against T7 phage infection by inhibiting viral polymerase-dependent transcription, suggesting that it has an antiviral mechanism of action similar to that of animal viperin. Our results reveal a class of potential natural antiviral compounds produced by bacterial immune systems."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-020-2762-2"xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-020-2762-2"xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Amitai G."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Amitai G."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Avraham C."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Avraham C."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Bernheim A."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Bernheim A."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Meitav G."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Meitav G."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Melamed S."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Melamed S."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Millman A."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Millman A."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Ofir G."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Ofir G."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Sorek R."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Sorek R."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Tal N."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Tal N."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Rosenberg M.M."xsd:string |
| http://purl.uniprot.org/citations/32937646 | http://purl.uniprot.org/core/author | "Rosenberg M.M."xsd:string |