| http://purl.uniprot.org/citations/32938678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32938678 | http://www.w3.org/2000/01/rdf-schema#comment | "How time is measured by neural stem cells during temporal neurogenesis has remained unresolved. By combining experiments and computational modeling, we define a Shh/Gli-driven three-node timer underlying the sequential generation of motor neurons (MNs) and serotonergic neurons in the brainstem. The timer is founded on temporal decline of Gli-activator and Gli-repressor activities established through down-regulation of Gli transcription. The circuitry conforms an incoherent feed-forward loop, whereby Gli proteins not only promote expression of Phox2b and thereby MN-fate but also account for a delayed activation of a self-promoting transforming growth factor-β (Tgfβ) node triggering a fate switch by repressing Phox2b. Hysteresis and spatial averaging by diffusion of Tgfβ counteract noise and increase temporal accuracy at the population level, providing a functional rationale for the intrinsically programmed activation of extrinsic switch signals in temporal patterning. Our study defines how time is reliably encoded during the sequential specification of neurons."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.aba8196"xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Dias J.M."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Matise M.P."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Alexeyenko A."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Vollmer J."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Ericson J."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Iber D."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Boareto M."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Alekseenko Z."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Jeggari A."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/author | "Kozhevnikova M."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/pages | "eaba8196"xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/title | "A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells."xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/32938678 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32938678 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-32938678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32938678 |