| http://purl.uniprot.org/citations/32940078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32940078 | http://www.w3.org/2000/01/rdf-schema#comment | "Aim: This study aimed to investigate the expression of microRNA-505 (miR-505) and explore its clinical significance, biological function and mechanisms in hepatocellular carcinoma (HCC). Methods: Expression of miR-505 was measured in 128 paired HCC tissues and five cell lines by quantitative real-time polymerase chain reaction (qRT-PCR). MTT assay, Transwell migration, invasion assays and apoptosis assay were performed to explore the functional role of miR-505. The target gene of miR-505 was assessed using the bioinformatics assay and the related signaling pathway was confirmed using western blot. Results: Expression of miR-505 in HCC serum and tissues were downregulated. The overexpression of miR-505 in HCC cells inhibited cell proliferation and metastasis, as well as enhanced cell apoptosis by directly downregulating heterogeneous nuclear ribonucleoprotein M (HNRNPM). The activity of the Wnt/β-catenin signaling pathway was suppressed by the overexpression of miR-505 but was promoted by the upregulation of HNRNPM. Conclusion: The results suggest that the regulation of miR-505/HNRNPM may be a novel strategy to improve the targeted therapy of HCC."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.org/dc/terms/identifier | "doi:10.2217/bmm-2019-0511"xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Cai Q."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Chi X."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Lv L."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/author | "Pan F."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/name | "Biomark Med"xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/pages | "981-996"xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/title | "microR-505/heterogeneous nuclear ribonucleoprotein M inhibits hepatocellular carcinoma cell proliferation and induces cell apoptosis through the Wnt/beta-catenin signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/32940078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32940078 |
| http://purl.uniprot.org/citations/32940078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32940078 |
| http://purl.uniprot.org/uniprot/#_P52272-mappedCitation-32940078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32940078 |
| http://purl.uniprot.org/uniprot/#_Q59ES8-mappedCitation-32940078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32940078 |
| http://purl.uniprot.org/uniprot/#_Q7KYM9-mappedCitation-32940078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32940078 |
| http://purl.uniprot.org/uniprot/#_Q6P2D7-mappedCitation-32940078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32940078 |
| http://purl.uniprot.org/uniprot/#_Q8TCM5-mappedCitation-32940078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32940078 |
| http://purl.uniprot.org/uniprot/P52272 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32940078 |