| http://purl.uniprot.org/citations/32940604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32940604 | http://www.w3.org/2000/01/rdf-schema#comment | "Synapses are fundamental information processing units that rely on voltage-gated Ca2+ (Cav) channels to trigger Ca2+-dependent neurotransmitter release. Cav channels also play Ca2+-independent roles in other biological contexts, but whether they do so in axon terminals is unknown. Here, we addressed this unknown with respect to the requirement for Cav1.4 L-type channels for the formation of rod photoreceptor synapses in the retina. Using a mouse strain expressing a non-conducting mutant form of Cav1.4, we report that the Cav1.4 protein, but not its Ca2+ conductance, is required for the molecular assembly of rod synapses; however, Cav1.4 Ca2+ signals are needed for the appropriate recruitment of postsynaptic partners. Our results support a model in which presynaptic Cav channels serve both as organizers of synaptic building blocks and as sources of Ca2+ ions in building the first synapse of the visual pathway and perhaps more broadly in the nervous system."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.62184"xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Williams B."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Hagen J."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Yadav R.P."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Baker S.A."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Hoon M."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Kerov V."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Della Santina L."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Artemyev N."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Randall K.L."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Maddox J.W."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/author | "Derr P.J."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/pages | "e62184"xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/title | "A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse."xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32940604 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32940604 |
| http://purl.uniprot.org/citations/32940604 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32940604 |
| http://purl.uniprot.org/uniprot/#_B1AVA4-mappedCitation-32940604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32940604 |
| http://purl.uniprot.org/uniprot/#_B1AVA5-mappedCitation-32940604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32940604 |
| http://purl.uniprot.org/uniprot/#_B1AVA6-mappedCitation-32940604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32940604 |