| http://purl.uniprot.org/citations/32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32941674 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of programmed cell death ligand (PD-L1) is associated with poor prognosis in breast cancer. Understanding the regulation of PD-L1 expression in breast cancer could provide a new strategy for breast cancer treatment. Here, we demonstrate that moesin (MSN) phosphorylation by Rho-associated protein kinase (ROCK) stabilizes PD-L1 protein levels. Our results indicate that phosphorylated MSN may compete with the E3 ubiquitin ligase SPOP for binding PD-L1. ROCK inhibition via the Y-27632 inhibitor or MSN silencing decreased PD-L1 expression, resulting in T-cell activation both in vitro and in vivo. Administration of Y-27632 into immunocompetent Balb/c mice bearing breast tumors suppressed tumor progression and enhanced CD4+ and CD8+ T-cell infiltration. RNA-seq analysis of Y-27632-treated mouse tumors revealed that ROCK inhibition upregulated several immune response genes. However, the combination of Y-27632 and an anti-PD-1 antibody did not show additive or synergistic effects due to reduced PD-L1 in the presence of Y-27632. Our study unravels a previously unappreciated mechanism of PD-L1 regulation through the ROCK-MSN pathway. Moreover, we found that ROCK inhibitors could be combined with breast cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://purl.org/dc/terms/identifier | "doi:10.1002/1878-0261.12804"xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://purl.uniprot.org/core/author | "Su Y."xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://purl.uniprot.org/core/author | "Xu B."xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://purl.uniprot.org/core/author | "Meng F."xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32941674 | http://purl.uniprot.org/core/name | "Mol Oncol"xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://purl.uniprot.org/core/pages | "2701-2712"xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://purl.uniprot.org/core/title | "Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/32941674 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32941674 |
| http://purl.uniprot.org/citations/32941674 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32941674 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TKR9-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DU05-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
| http://purl.uniprot.org/uniprot/#_B7Z4C7-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
| http://purl.uniprot.org/uniprot/#_B4DRJ9-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
| http://purl.uniprot.org/uniprot/#_D9ZGF8-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
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| http://purl.uniprot.org/uniprot/#_P26038-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
| http://purl.uniprot.org/uniprot/#_Q13464-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
| http://purl.uniprot.org/uniprot/#_Q0GN75-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
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| http://purl.uniprot.org/uniprot/#_O75116-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |
| http://purl.uniprot.org/uniprot/#_Q9NZQ7-mappedCitation-32941674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32941674 |