| http://purl.uniprot.org/citations/32942189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32942189 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal Inhibitory Receptor on Leukocytes-1 (SIRL-1) is expressed on human blood monocytes and granulocytes and inhibits myeloid effector functions. On monocytes, but not granulocytes, SIRL-1 expression is low or absent in individuals with the single nucleotide polymorphism (SNP) rs612529C. The expression of SIRL-1 in tissue and the influence of rs612529 hereon is currently unknown. Here, we used flow cytometry to determine SIRL-1 expression on immune cells in human blood and three barrier tissues; skin, colon and lung. SIRL-1 was expressed by virtually all neutrophils and eosinophils in these tissues. In contrast, SIRL-1 was not expressed by monocyte-derived cells in skin and colon, whereas it was highly expressed by lung classical monocytes. Lung monocytes from individuals with a rs612529C allele had decreased SIRL-1 expression, consistent with the genotype association in blood. Within the different monocyte subsets in blood and lung, SIRL-1 expression was highest in classical monocytes and lowest in nonclassical monocytes. SIRL-1 was not expressed by dendritic cells in blood and barrier tissues. Together, these results indicate that SIRL-1 is differentially expressed on phagocyte subsets in blood and barrier tissues, and that its expression on monocytes is genotype- and tissue-specific. Immune regulation of monocytes by SIRL-1 may be of particular importance in the lung."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2020.104199"xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "de Jong E.C."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "Giovannone B."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "Gollnast D."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "Meyaard L."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "Oldenburg B."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "Hijnen D."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "van der Vlist M."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "Lutter L."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "Westerlaken G.H.A."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "van Capel T.M.M."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/author | "von Richthofen H.J."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/pages | "104199"xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/title | "Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon."xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://purl.uniprot.org/core/volume | "357"xsd:string |
| http://purl.uniprot.org/citations/32942189 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32942189 |
| http://purl.uniprot.org/citations/32942189 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32942189 |
| http://purl.uniprot.org/uniprot/#_D2E0V1-mappedCitation-32942189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32942189 |
| http://purl.uniprot.org/uniprot/#_D2DJS5-mappedCitation-32942189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32942189 |
| http://purl.uniprot.org/uniprot/#_D2DJS6-mappedCitation-32942189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32942189 |
| http://purl.uniprot.org/uniprot/#_Q6UX27-mappedCitation-32942189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32942189 |