| http://purl.uniprot.org/citations/32943521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32943521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32943521 | http://www.w3.org/2000/01/rdf-schema#comment | "Production of small ribosomal subunits initially requires the formation of a 90S precursor followed by an enigmatic process of restructuring into the primordial pre-40S subunit. We elucidate this process by biochemical and cryo-electron microscopy analysis of intermediates along this pathway in yeast. First, the remodeling RNA helicase Dhr1 engages the 90S pre-ribosome, followed by Utp24 endonuclease-driven RNA cleavage at site A1, thereby separating the 5'-external transcribed spacer (ETS) from 18S ribosomal RNA. Next, the 5'-ETS and 90S assembly factors become dislodged, but this occurs sequentially, not en bloc. Eventually, the primordial pre-40S emerges, still retaining some 90S factors including Dhr1, now ready to unwind the final small nucleolar U3-18S RNA hybrid. Our data shed light on the elusive 90S to pre-40S transition and clarify the principles of assembly and remodeling of large ribonucleoproteins."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abb4119"xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abb4119"xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Hurt E."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Hurt E."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Ameismeier M."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Ameismeier M."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "La Venuta G."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "La Venuta G."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Lau B."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/author | "Lau B."xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/pages | "1470-1476"xsd:string |
| http://purl.uniprot.org/citations/32943521 | http://purl.uniprot.org/core/pages | "1470-1476"xsd:string |