| http://purl.uniprot.org/citations/32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32948625 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycomb group (PcG) proteins are an important group of transcriptional repressors that act by modifying chromatin. PcG target genes are covered by the repressive chromatin mark H3K27me3. Polycomb repressive complex 2 (PRC2) is a multiprotein complex that is responsible for generating H3K27me3. In Drosophila, PRC2 is recruited by Polycomb Response Elements (PREs) and then trimethylates flanking nucleosomes, spreading the H3K27me3 mark over large regions of the genome, the "Polycomb domains." What defines the boundary of a Polycomb domain? There is experimental evidence that insulators, PolII, and active transcription can all form the boundaries of Polycomb domains. Here we divide the boundaries of larval Polycomb domains into six different categories. In one category, genes are transcribed toward the Polycomb domain, where active transcription is thought to stop the spreading of H3K27me3. In agreement with this, we show that introducing a transcriptional terminator into such a transcription unit causes an extension of the Polycomb domain. Additional data suggest that active transcription of a boundary gene may restrict the range of enhancer activity of a Polycomb-regulated gene."xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.120.303642"xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/author | "Fujioka M."xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/author | "De S."xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/author | "Jaynes J.B."xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/author | "Kassis J.A."xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/author | "Chan F.W."xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/author | "Gehred N.D."xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/pages | "689-700"xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/title | "Defining the Boundaries of Polycomb Domains in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://purl.uniprot.org/core/volume | "216"xsd:string |
| http://purl.uniprot.org/citations/32948625 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32948625 |
| http://purl.uniprot.org/citations/32948625 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32948625 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEM1-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFE3-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |
| http://purl.uniprot.org/uniprot/#_A8DYA3-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |
| http://purl.uniprot.org/uniprot/#_A1Z8M2-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |
| http://purl.uniprot.org/uniprot/#_P02299-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |
| http://purl.uniprot.org/uniprot/#_Q24478-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |
| http://purl.uniprot.org/uniprot/#_P05527-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |
| http://purl.uniprot.org/uniprot/#_P02836-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |
| http://purl.uniprot.org/uniprot/#_Q960I3-mappedCitation-32948625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32948625 |