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http://purl.uniprot.org/citations/32964059http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32964059http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the role of TAM receptors in rheumatoid arthritis (RA) by determining synovial tissue TAM receptor expression, synovial fluid levels of soluble TAM receptors, and the relationship between soluble TAM receptors, joint inflammation and disease activity.

Methods

TAM receptor expression was determined by immunohistochemistry on the synovium from RA and osteoarthritis (OA) patients. Soluble (s) Tyro3, sAxl, sMer, and their ligand Gas6 were measured by ELISA in the synovial fluid of RA (n = 28) and OA (n = 12) patients and cytokine levels by multiplex immunoassay in RA samples. Correlation analyses were performed among sTAM receptors with local cytokine levels; systemic disease parameters like erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and anticyclic citrullinated peptide antibodies (ACPA); and disease activity scores (DAS28-ESR) in RA patients.

Results

TAM receptors were expressed on different locations in the synovial tissue (lining, sublining, and blood vessels), and a similar expression pattern was observed in RA and OA patients. Synovial fluid sTyro3 and sMer were significantly enhanced in RA compared to OA patients, whereas no significant differences in sAxl and Gas6 levels were found. In RA samples, sTyro3 levels, but not sMer, correlated positively with proinflammatory local cytokines and the systemic factor erythrocyte sedimentation rate. Moreover, stratification analysis showed high sTyro3 levels positively correlated with higher DAS28-ESR and in RF and ACPA double positive RA patients.

Conclusion

sTyro3 in the synovial fluid of RA patients correlates with local inflammatory molecules and systemic disease activity. These findings suggest that the reduced negative control of cell activation by TAM receptors due to their shedding in the synovial fluid, mainly sTyro3, favoring joint inflammation in RA patients."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.org/dc/terms/identifier"doi:10.1155/2020/9690832"xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"van de Loo F.A.J."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"Amaral F.A."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"van der Kraan P.M."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"Koenders M.I."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"Thurlings R.M."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"Vago J.P."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"Waterborg C.E.J."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"van Lent P.L.E.M."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/author"Vullings J."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/name"J Immunol Res"xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/pages"9690832"xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/title"Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis."xsd:string
http://purl.uniprot.org/citations/32964059http://purl.uniprot.org/core/volume"2020"xsd:string
http://purl.uniprot.org/citations/32964059http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32964059
http://purl.uniprot.org/citations/32964059http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32964059
http://purl.uniprot.org/uniprot/#_B4DIA4-mappedCitation-32964059http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32964059
http://purl.uniprot.org/uniprot/#_Q06418-mappedCitation-32964059http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32964059
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http://purl.uniprot.org/uniprot/#_Q15879-mappedCitation-32964059http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32964059
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