| http://purl.uniprot.org/citations/32966791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32966791 | http://www.w3.org/2000/01/rdf-schema#comment | "The processes that control where higher eukaryotic cells initiate DNA replication throughout the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates critical final steps in formation of the activated replicative helicase prior to initiation of replication. Here, we map the genome-wide distribution of the MTBP subunit of this complex in human cells. Our results indicate that MTBP binds to at least 30,000 sites in the genome. A majority of these sites reside in regions of open chromatin that contain transcriptional-regulatory elements (e.g., promoters, enhancers, and super-enhancers), which are known to be preferred areas for initiation of replication. Furthermore, many binding sites encompass two genomic features: a nucleosome-free DNA sequence (e.g., G-quadruplex DNA or AP-1 motif) and a nucleosome bearing histone marks characteristic of open chromatin, such as H3K4me2. Taken together, these findings indicate that Treslin-MTBP associates coordinately with multiple genomic signals to promote initiation of replication."xsd:string |
| http://purl.uniprot.org/citations/32966791 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.108178"xsd:string |
| http://purl.uniprot.org/citations/32966791 | http://purl.uniprot.org/core/author | "Dunphy W.G."xsd:string |
| http://purl.uniprot.org/citations/32966791 | http://purl.uniprot.org/core/author | "Kumagai A."xsd:string |
| http://purl.uniprot.org/citations/32966791 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32966791 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32966791 | http://purl.uniprot.org/core/pages | "108178"xsd:string |
| http://purl.uniprot.org/citations/32966791 | http://purl.uniprot.org/core/title | "Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication."xsd:string |
| http://purl.uniprot.org/citations/32966791 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/32966791 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32966791 |
| http://purl.uniprot.org/citations/32966791 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32966791 |
| http://purl.uniprot.org/uniprot/#_Q96DY7-mappedCitation-32966791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32966791 |
| http://purl.uniprot.org/uniprot/#_Q7Z2Z1-mappedCitation-32966791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32966791 |
| http://purl.uniprot.org/uniprot/Q96DY7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32966791 |
| http://purl.uniprot.org/uniprot/Q7Z2Z1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32966791 |