http://purl.uniprot.org/citations/32986350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/32986350 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundCurrent study investigates the role of Oct4, Nanog and CD24 in locally-advanced oral squamous cell carcinoma (OSCC), to evaluate whether the expression of these markers can predict efficacy of neoadjuvant-chemo-radiotherapy and survival of patients.MethodsBiomarker expression was evaluated in 50 homogenously treated patients of locally-advanced OSCC.ResultsClinical response was complete in 30% (n=15), partial response in 46% (n=23), no response in 24% (n=12). Pathologically, 74% patents (n=37) were responders and 26% were non-responders (n=13). Biomarker-overexpression was seen in 46% cases for Oct4, 54% cases for Nanog and 58% cases for CD24. Oct4, Nanog and CD24 expression showed significant correlation with clinical and pathological response (p <0.05). Three year recurrence-free survival was 71%, overall survival was 66%. Post-treatment advanced pathological N (ypN), post treatment advanced pathological TNM (ypTNM) stage, clinical non-response, pathologic non-response, positive/high expression of all three biomarkers had a significant negative impact on recurrence-free and overall survival.ConclusionsExpressions of Oct4, Nanog and CD24 have significant association with treatment response and survival in patients with locally advanced OSCC treated with neoadjuvant chemo-radiation. Survival of these patients is significantly affected by ypN stage, ypTNM stage, expression of all three biomarkers, clinical and pathological response to neoadjuvant therapy. ."xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.org/dc/terms/identifier | "doi:10.31557/apjcp.2020.21.9.2539"xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/author | "Gupta S."xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/author | "Mishra S."xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/author | "Arora A."xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/author | "Tiwari V."xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/author | "Anand N."xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/author | "Husain N."xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/name | "Asian Pac J Cancer Prev"xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/pages | "2539-2547"xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/title | "Increased Expression of Oct4, Nanog and CD24 Predicts Poor Response to Chemo-Radiotherapy and Unfavourable Prognosis in Locally Advanced Oral Squamous Cell Carcinoma."xsd:string |
http://purl.uniprot.org/citations/32986350 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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