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http://purl.uniprot.org/citations/32986659http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32986659http://www.w3.org/2000/01/rdf-schema#comment"

Background

HSP60 and its partner HSP10 are members of heat shock proteins (HSPs) family, which help mitochondrial protein to fold correctly. Mcl-1, a member of the Bcl-2 family, plays a crucial role in regulation of cell apoptosis. Aberrant expression of HSP10, HSP60 and Mcl-1 is involved in the development of many tumors.

Objective

To examine the association between expression of HSP10, HSP60 and Mcl-1 and clinicopathological features of non-small cell lung cancer (NSCLC).

Methods

Tissue microarrays including 53 non-cancerous lung tissues (Non-CLT) and 354 surgically resected NSCLC were stained with anti-HSP10, anti-HSP60 and anti-Mcl-1 antibodies respectively by immunohistochemistry.

Results

Higher expression of HSP10, HSP60 and Mcl-1 was found in NSCLC compared with Non-CLT. Both individual and combined HSP10 and HSP60 expression in patients with clinical stage III was higher than that in stage I ∼ II. Expression of HSP10 showed a positive correlation with HSP60 and Mcl-1. Overall survival time of NSCLC patients was remarkably shorter with elevated expression of HSP10, HSP60 and Mcl-1 alone and in combination. Moreover overexpression of HSP10 and Mcl-1 was poor independent prognostic factor for lung adenocarcinoma patients.

Conclusions

High expression of HSP10, HSP60 and Mcl-1 might act as novel biomarker of poor prognosis for NSCLC patients."xsd:string
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http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Luo J."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Liu S."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Tang Y."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Yang Y."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Zheng H."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Zhan Y."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Feng J."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Fan S."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Wen Q."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/author"Zang H."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/name"Cancer Biomark"xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/pages"85-94"xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/title"Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients."xsd:string
http://purl.uniprot.org/citations/32986659http://purl.uniprot.org/core/volume"30"xsd:string
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