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Background

In order for aging to evolve in response to a declining strength of selection with age, a genetic architecture that allows for mutations with age-specific effects on organismal performance is required. Our understanding of how selective effects of individual mutations are distributed across ages is however poor. Established evolutionary theories assume that mutations causing aging have negative late-life effects, coupled to either positive or neutral effects early in life. New theory now suggests evolution of aging may also result from deleterious mutations with increasing negative effects with age, a possibility that has not yet been empirically explored.

Results

To directly test how the effects of deleterious mutations are distributed across ages, we separately measure age-specific effects on fecundity for each of 20 mutations in Drosophila melanogaster. We find that deleterious mutations in general have a negative effect that increases with age and that the rate of increase depends on how deleterious a mutation is early in life.

Conclusions

Our findings suggest that aging does not exclusively depend on genetic variants assumed by the established evolutionary theories of aging. Instead, aging can result from deleterious mutations with negative effects that amplify with age. If increasing negative effect with age is a general property of deleterious mutations, the proportion of mutations with the capacity to contribute towards aging may be considerably larger than previously believed."xsd:string
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http://purl.uniprot.org/citations/32993647http://purl.uniprot.org/core/author"Thompson J."xsd:string
http://purl.uniprot.org/citations/32993647http://purl.uniprot.org/core/author"Elias P."xsd:string
http://purl.uniprot.org/citations/32993647http://purl.uniprot.org/core/author"Friberg U."xsd:string
http://purl.uniprot.org/citations/32993647http://purl.uniprot.org/core/author"Brengdahl M.I."xsd:string
http://purl.uniprot.org/citations/32993647http://purl.uniprot.org/core/author"Kimber C.M."xsd:string
http://purl.uniprot.org/citations/32993647http://purl.uniprot.org/core/date"2020"xsd:gYear
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http://purl.uniprot.org/citations/32993647http://purl.uniprot.org/core/title"Deleterious mutations show increasing negative effects with age in Drosophila melanogaster."xsd:string
http://purl.uniprot.org/citations/32993647http://purl.uniprot.org/core/volume"18"xsd:string
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