| http://purl.uniprot.org/citations/33000497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33000497 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibro/adipogenic progenitors (FAPs) are the main cellular source of fatty degeneration in muscle injury; however, the underlying mechanism of FAP adipogenesis in muscle degeneration needs to be further examined. Matrix metalloproteinase 14 (MMP-14) has been reported to induce the adipogenesis of 3T3-L1 preadipocytes, but whether MMP-14 also regulates the differentiation of FAPs remains unclear. To investigate whether and how MMP-14 regulates FAP adipogenesis and fatty infiltration in muscle degeneration, we examined MMP-14 expression in degenerative muscles and tested the effect of MMP-14 on FAP adipogenesis in vitro and in vivo. As expected, MMP-14 enhanced FAP adipogenesis and fatty infiltration in degenerative muscles; moreover, blocking endogenous MMP-14 in injured muscles facilitated muscle repair. Further investigations revealed that Kruppel-like factor 6 (KLF6) was a transcription factor associated with MMP-14 and acted as an "on-off" switch in the differentiation of FAPs into adipocytes or myofibroblasts. Moreover, KLF6 was the target gene of miR-22-3p, which was downregulated during FAP adipogenesis both in vitro and in vivo, and overexpression of miR-22-3p markedly prevented FAP adipogenesis and attenuated fatty degeneration in muscles. Our study revealed that miR-22-3p/KLF6/MMP-14 is a novel pathway in FAP adipogenesis and that inhibiting KLF6 is a potential strategy for the treatment of muscular degenerative diseases."xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.202000506r"xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/author | "Yue Z."xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/author | "Chang-Qing L."xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/author | "Sheng-Xiang A."xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/author | "Wen-Jie Z."xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/pages | "12691-12701"xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/title | "mir-22-3p/KLF6/MMP14 axis in fibro-adipogenic progenitors regulates fatty infiltration in muscle degeneration."xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/33000497 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33000497 |
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