| http://purl.uniprot.org/citations/33004979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33004979 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary sclerosing cholangitis (PSC) is a progressive fibrosing cholestatic liver disease that is strongly associated with inflammatory bowel disease (IBD). PSC-associated IBD (PSC-IBD) displays a unique phenotype characterized by right-side predominant colon inflammation and increased risk of colorectal cancer compared to non-PSC-IBD. The frequent association and unique phenotype of PSC-IBD suggest distinctive underlying disease mechanisms from other chronic liver diseases or IBD alone. Multidrug resistance protein 2 knockout (Mdr2-/-) mice develop spontaneous cholestatic liver injury and fibrosis mirroring human PSC. As a novel model of PSC-IBD, we treated Mdr2-/- mice with dextran sulfate sodium (DSS) to chemically induce colitis (Mdr2-/-/DSS). Mdr2-/- mice demonstrate alterations in fecal bile acid composition and enhanced colitis susceptibility with increased colonic adhesion molecule expression, particularly mucosal addressin-cell adhesion molecule 1 (MAdCAM-1). In vitro, ursodeoxycholic acid (UDCA) co-treatment resulted in a dose dependent attenuation of TNF-α-induced endothelial MAdCAM-1 expression. In the combined Mdr2-/-/DSS model, UDCA supplementation attenuated colitis severity and downregulated intestinal MAdCAM-1 expression. These findings suggest a potential mechanistic role for alterations in bile acid signaling in modulating MAdCAM-1 expression and colitis susceptibility in cholestasis-associated colitis. Together, our findings provide a novel model and new insight into the pathogenesis and potential treatment of PSC-IBD."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41385-020-00347-6"xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Ju C."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Colgan S.P."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Orlicky D.J."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Shearn C.T."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Gao R.Y."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Lanis J.M."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Alexeev E.E."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Battista K.D."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Cartwright I.M."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Fennimore B.P."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/author | "Kostelecky R.E."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/name | "Mucosal Immunol"xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/pages | "479-490"xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/title | "Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis."xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/33004979 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33004979 |
| http://purl.uniprot.org/citations/33004979 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33004979 |
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| http://purl.uniprot.org/uniprot/#_Q3UVR1-mappedCitation-33004979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33004979 |
| http://purl.uniprot.org/uniprot/#_Q61826-mappedCitation-33004979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33004979 |