DESCRIBE <http://purl.uniprot.org/citations/33015777>

Subject	Predicate	Object
http://purl.uniprot.org/citations/33015777	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33015777	http://www.w3.org/2000/01/rdf-schema#comment	" Objective MicroRNAs (miRNA) are aberrantly expressed in various human cancers, including colorectal cancer (CRC). We aim to investigate the functional role and underlying mechanism of miR-144 in CRC. Patients and methods The expressional level of miR-144 and pre-leukemia transcription factor 3 (PBX3) in CRC tissues and cells was confirmed by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) and Western blot. The migration and invasion of CRC cells were detected by transwell assay. Luciferase reporter assay was performed to determine the specific target of miR-144 in CRC cells. Results The results displayed that miR-144 expression was significantly decreased in CRC tissues and cells compared to that in normal controls. Additionally, miR-144 mimic suppressed, while miR-144 inhibitor promoted the ability of CRC cell migration and invasion. More importantly, PBX3 was the direct target of miR-144 in regulating CRC development and PBX3 could reverse the inhibitory effect of miR-144 mimic on CRC cells. PBX3 expression was significantly increased in CRC and negatively correlated with miR-144 expression. Conclusions In conclusion, miR-144 suppressed CRC cell migration and invasion by targeting PBX3, suggesting its potential value in the diagnosis and treatment of CRC."xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.org/dc/terms/identifier	"doi:10.26355/eurrev_202009_23019"xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/author	"Zhang Y."xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/author	"Cheng B."xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/author	"Li W.L."xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/author	"Wu Z.W."xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/author	"Cui Z.C."xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/date	"2020"xsd:gYear
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/name	"Eur Rev Med Pharmacol Sci"xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/pages	"9361-9369"xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/title	"MiR-144 inhibits colorectal cancer cell migration and invasion by regulating PBX3."xsd:string
http://purl.uniprot.org/citations/33015777	http://purl.uniprot.org/core/volume	"24"xsd:string
http://purl.uniprot.org/citations/33015777	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/33015777
http://purl.uniprot.org/citations/33015777	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/33015777
http://purl.uniprot.org/uniprot/#_B7Z4A9-mappedCitation-33015777	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33015777
http://purl.uniprot.org/uniprot/#_B7Z5Q0-mappedCitation-33015777	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33015777
http://purl.uniprot.org/uniprot/#_P40426-mappedCitation-33015777	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33015777
http://purl.uniprot.org/uniprot/#_Q96AL5-mappedCitation-33015777	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33015777
http://purl.uniprot.org/uniprot/Q96AL5	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33015777
http://purl.uniprot.org/uniprot/P40426	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33015777
http://purl.uniprot.org/uniprot/B7Z5Q0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33015777
http://purl.uniprot.org/uniprot/B7Z4A9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33015777