| http://purl.uniprot.org/citations/33020597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33020597 | http://www.w3.org/2000/01/rdf-schema#comment | "PIWI-interacting RNAs (piRNAs) are abundantly expressed during cardiac hypertrophy. However, their functions and molecular mechanisms remain unknown. Here, we identified a cardiac-hypertrophy-associated piRNA (CHAPIR) that promotes pathological hypertrophy and cardiac remodelling by targeting METTL3-mediated N6-methyladenosine (m6A) methylation of Parp10 mRNA transcripts. CHAPIR deletion markedly attenuates cardiac hypertrophy and restores heart function, while administration of a CHAPIR mimic enhances the pathological hypertrophic response in pressure-overloaded mice. Mechanistically, CHAPIR-PIWIL4 complexes directly interact with METTL3 and block the m6A methylation of Parp10 mRNA transcripts, which upregulates PARP10 expression. The CHAPIR-dependent increase in PARP10 promotes the mono-ADP-ribosylation of GSK3β and inhibits its kinase activity, which results in the accumulation of nuclear NFATC4 and the progression of pathological hypertrophy. Hence, our findings reveal that a piRNA-mediated RNA epigenetic mechanism is involved in the regulation of cardiac hypertrophy and that the CHAPIR-METTL3-PARP10-NFATC4 signalling axis could be therapeutically targeted for treating pathological hypertrophy and maladaptive cardiac remodelling."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41556-020-0576-y"xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Ju J."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Liu C.Y."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Wang K."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Zhai M."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Dong Y.H."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Yu T."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Gao X.Q."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Li X.M."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Wang Y.H."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Li P.F."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Shan C."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Zhang Y.H."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Zhao X.M."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Chen X.Z."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Zhou L.Y."xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Wang K.'"xsd:string |
| http://purl.uniprot.org/citations/33020597 | http://purl.uniprot.org/core/author | "Qian L.L."xsd:string |