| http://purl.uniprot.org/citations/33022229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33022229 | http://www.w3.org/2000/01/rdf-schema#comment | "The gut epithelium is populated by intraepithelial lymphocytes (IELs), a heterogeneous T cell population with cytotoxic and regulatory properties, which can be acquired at the epithelial layer. However, the role of T cell receptor (TCR) in this process remains unclear. Single-cell transcriptomic analyses revealed distinct clonal expansions between cell states, with CD4+CD8αα+ IELs being one of the least diverse populations. Conditional deletion of TCR on differentiating CD4+ T cells or of major histocompatibility complex (MHC) class II on intestinal epithelial cells prevented CD4+CD8αα+ IEL differentiation. However, TCR ablation on differentiated CD4+CD8αα+ IELs or long-term cognate antigen withdraw did not affect their maintenance. TCR re-engagement of antigen-specific CD4+CD8αα+ IELs by Listeria monocytogenes did not alter their state but correlated with reduced bacterial invasion. Thus, local antigen recognition is an essential signal for differentiation of CD4+ T cells at the epithelium, yet differentiated IELs are able to preserve an effector program in the absence of TCR signaling."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2020.09.003"xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "Victora G.D."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "Mucida D."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "London M."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "Bortolatto J."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "Bilate A.M."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "Mesin L."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "Castro T.B.R."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "Harnagel A."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/author | "Kongthong S."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/pages | "1001-1014.e20"xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/title | "T Cell Receptor Is Required for Differentiation, but Not Maintenance, of Intestinal CD4+ Intraepithelial Lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/33022229 | http://purl.uniprot.org/core/volume | "53"xsd:string |
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