| http://purl.uniprot.org/citations/33027652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33027652 | http://www.w3.org/2000/01/rdf-schema#comment | "The cysteine protease inhibitor Cystatin C (CST3) is highly expressed in the brains of multiple sclerosis (MS) patients and C57BL/6J mice with experimental autoimmune encephalomyelitis (EAE; a model of MS), but its roles in the diseases are unknown. Here, we show that CST3 plays a detrimental function in myelin oligodendrocyte glycoprotein 35-55 (MOG35-55)-induced EAE but only in female animals. Female Cst3 null mice display significantly lower clinical signs of disease compared to wild-type (WT) littermates. This difference is associated with reduced interleukin-6 production and lower expression of key proteins (CD80, CD86, major histocompatibility complex [MHC] II, LC3A/B) involved in antigen processing, presentation, and co-stimulation in antigen-presenting cells (APCs). In contrast, male WT and Cst3-/- mice and cells show no differences in EAE signs or APC function. Further, the sex-dependent effect of CST3 in EAE is sensitive to gonadal hormones. Altogether, we have shown that CST3 has a sex-dependent role in MOG35-55-induced EAE."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.108236"xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Gordon P."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Nguyen M.D."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Levy E."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Balakrishnan A."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Grubb A."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Jirik F.R."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Schuurmans C."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Visser F."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Frederick A."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Dunn S.E."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Ousman S.S."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Palmer A.L."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Finlay T.M."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Hoghooghi V."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/author | "Merkens J.E."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/pages | "108236"xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/title | "Cystatin C Plays a Sex-Dependent Detrimental Role in Experimental Autoimmune Encephalomyelitis."xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/33027652 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33027652 |