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http://purl.uniprot.org/citations/33034926http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

The interleukin (IL)-36 cytokines include IL-36α, IL-36β, IL-36γ, and IL-36Ra. Little was known about their roles in type 2 diabetes mellitus (T2DM).

Methods

The study included 40 T2DM patients and 42 healthy control subjects. The anthropometric and biochemical measurements were performed using automatic biochemical analyzer, high-performance liquid chromatography, and electrochemiluminescence immunoassay. Circulating IL-36α, IL-36γ, IL-36Ra, and IL-17 levels were determined by enzyme-linked immunosorbent assay.

Results

Serum IL-36α, IL-36γ, and IL-17 levels in T2DM patients were significantly higher than those in controls, whereas serum IL-36Ra levels in T2DM patients were lower. Correlation analysis showed that serum IL-36α was positively correlated with high sensitivity C-reactive protein. Serum IL-36α was negatively correlated with IL-36Ra. Serum IL-17 was negatively correlated with low-density lipoprotein cholesterol.

Conclusions

This study demonstrated that T2DM patients displayed increased IL-36α and IL-36γ expression and decreased IL-36Ra expression. Moreover, the inflammatory cytokine levels were directly proportional to the inflammation and blood lipid levels. Our results suggest that IL-36 cytokines may be a new target for the diagnosis or treatment of T2DM."xsd:string
http://purl.uniprot.org/citations/33034926http://purl.org/dc/terms/identifier"doi:10.1002/jcla.23611"xsd:string
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/author"Chen S."xsd:string
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/author"Li M."xsd:string
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/author"Zhao T."xsd:string
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/name"J Clin Lab Anal"xsd:string
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/pages"e23611"xsd:string
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/title"Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation."xsd:string
http://purl.uniprot.org/citations/33034926http://purl.uniprot.org/core/volume"35"xsd:string
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