| http://purl.uniprot.org/citations/33044553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33044553 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinesin-14s are conserved molecular motors required for high-fidelity chromosome segregation, but their specific contributions to spindle function have not been fully defined. Here, we show that key functions of budding yeast Kinesin-14 Cik1-Kar3 are accomplished in a complex with Bim1 (yeast EB1). Genetic complementation of mitotic phenotypes identifies a novel KLTF peptide motif in the Cik1 N-terminus. We show that this motif is one element of a tripartite binding interface required to form a high-affinity Bim1-Cik1-Kar3 complex. Lack of Bim1-binding by Cik1-Kar3 delays cells in mitosis and impairs microtubule bundle organization and dynamics. Conversely, constitutive targeting of Cik1-Kar3 to microtubule plus ends induces the formation of nuclear microtubule bundles. Cells lacking the Bim1-Cik1-Kar3 complex rely on the conserved microtubule bundler Ase1/PRC1 for metaphase spindle organization, and simultaneous loss of plus-end targeted Kar3 and Ase1 is lethal. Our results reveal the contributions of an EB1-Kinesin-14 complex for spindle formation as a prerequisite for efficient kinetochore clustering and bi-orientation."xsd:string |
| http://purl.uniprot.org/citations/33044553 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.202003072"xsd:string |
| http://purl.uniprot.org/citations/33044553 | http://purl.uniprot.org/core/author | "Westermann S."xsd:string |
| http://purl.uniprot.org/citations/33044553 | http://purl.uniprot.org/core/author | "Mollers B."xsd:string |
| http://purl.uniprot.org/citations/33044553 | http://purl.uniprot.org/core/author | "Kornakov N."xsd:string |
| http://purl.uniprot.org/citations/33044553 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33044553 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/33044553 | http://purl.uniprot.org/core/pages | "e202003072"xsd:string |
| http://purl.uniprot.org/citations/33044553 | http://purl.uniprot.org/core/title | "The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation."xsd:string |
| http://purl.uniprot.org/citations/33044553 | http://purl.uniprot.org/core/volume | "219"xsd:string |
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