| http://purl.uniprot.org/citations/33051544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33051544 | http://www.w3.org/2000/01/rdf-schema#comment | "P21-activated kinase 4 (PAK4), a member of serine/threonine kinases family is over-expressed in numerous cancer tumors and is associated with oncogenic cell proliferation, migration and invasion. Our recent work demonstrated that the SET-domain containing protein 6 (SETD6) interacts with and methylates PAK4 at chromatin in mammalian cells, leading to activation of the Wnt/β-catenin signaling pathway. In our current work, we identified lysine 473 (K473) on PAK4 as the primary methylation site by SETD6. Methylation of PAK4 at K473 activates β-catenin transcriptional activity and inhibits cell adhesion. Specific methylation of PAK4 at K473 also attenuates paxillin localization to focal adhesions leading to overall reduction in adhesion-related features, such as filopodia and actin structures. The altered adhesion of the PAK4 wild-type cells is accompanied with a decrease in the migrative and invasive characteristics of the cells. Taken together, our results suggest that methylation of PAK4 at K473 plays a vital role in the regulation of cell adhesion and migration."xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-74081-1"xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://purl.uniprot.org/core/author | "Levy D."xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://purl.uniprot.org/core/author | "Feldman M."xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://purl.uniprot.org/core/author | "Vershinin Z."xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33051544 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://purl.uniprot.org/core/pages | "17068"xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://purl.uniprot.org/core/title | "PAK4 methylation by the methyltransferase SETD6 attenuates cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33051544 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33051544 |
| http://purl.uniprot.org/citations/33051544 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33051544 |
| http://purl.uniprot.org/uniprot/#_P49023-mappedCitation-33051544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33051544 |
| http://purl.uniprot.org/uniprot/P49023 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33051544 |