| http://purl.uniprot.org/citations/33053331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33053331 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8+ T cells within the tumor microenvironment (TME) are exposed to various signals that ultimately determine functional outcomes. Here, we examined the role of the co-activating receptor CD226 (DNAM-1) in CD8+ T cell function. The absence of CD226 expression identified a subset of dysfunctional CD8+ T cells present in peripheral blood of healthy individuals. These cells exhibited reduced LFA-1 activation, altered TCR signaling, and a distinct transcriptomic program upon stimulation. CD226neg CD8+ T cells accumulated in human and mouse tumors of diverse origin through an antigen-specific mechanism involving the transcriptional regulator Eomesodermin (Eomes). Despite similar expression of co-inhibitory receptors, CD8+ tumor-infiltrating lymphocyte failed to respond to anti-PD-1 in the absence of CD226. Immune checkpoint blockade efficacy was hampered in Cd226-/- mice. Anti-CD137 (4-1BB) agonists also stimulated Eomes-dependent CD226 loss that limited the anti-tumor efficacy of this treatment. Thus, CD226 loss restrains CD8+ T cell function and limits the efficacy of cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2020.09.006"xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Braun M."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Martinez A."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Das I."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Bald T."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Verhoeyen E."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Goriely S."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Ayyoub M."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Dupre L."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Kassem S."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Lemaitre L."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Scarlata C.M."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Martinet L."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Saoudi A."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Peres M."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Avet-Loiseau H."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Mazieres J."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Morandi E."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Dejean A.S."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Gaud G."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Carrie N."xsd:string |
| http://purl.uniprot.org/citations/33053331 | http://purl.uniprot.org/core/author | "Guillerey C."xsd:string |