| http://purl.uniprot.org/citations/33054973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33054973 | http://www.w3.org/2000/01/rdf-schema#comment | "Microglia are the resident myeloid cells in the central nervous system (CNS). The majority of microglia rely on CSF1R signaling for survival. However, a small subset of microglia in mouse brains can survive without CSF1R signaling and reestablish the microglial homeostatic population after CSF1R signaling returns. Using single-cell transcriptomic analysis, we characterized the heterogeneous microglial populations under CSF1R inhibition, including microglia with reduced homeostatic markers and elevated markers of inflammatory chemokines and proliferation. Importantly, MAC2/Lgals3 was upregulated under CSF1R inhibition, and shared striking similarities with microglial progenitors in the yolk sac and immature microglia in early embryos. Lineage-tracing studies revealed that these MAC2+ cells were of microglial origin. MAC2+ microglia were also present in non-treated adult mouse brains and exhibited immature transcriptomic signatures indistinguishable from those that survived CSF1R inhibition, supporting the notion that MAC2+ progenitor-like cells are present among adult microglia."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.51796"xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Fan L."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Gan L."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Zhan L."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Kodama L."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Wong M.Y."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Sohn P.D."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/author | "Mousa G.A."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/pages | "e51796"xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/title | "A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain."xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/33054973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33054973 |
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