| http://purl.uniprot.org/citations/33078631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33078631 | http://www.w3.org/2000/01/rdf-schema#comment | "Aim: Identification of aberrant hypermethylation in promoter regions of candidate genes to discover potential biomarkers for colorectal cancer. Materials & Methods: Genes BMP2, IRF4, KCNA1, LRRC7, NRG3, SLC27A6 and UNC5D were pre-selected in a bioinformatics study for their hypermethylation status in colorectal cancer. Methylation analysis was performed on 202 cancer tissue specimens to validate candidate genes. Results: Genes KCNA1 and UNC5D displayed methylation in 95.3 and 99.7% of The Cancer Genome Atlas dataset samples and in 96 and 98% of our experimentally tested samples, respectively. Conclusion:KCNA1 and UNC5D promoter hypermethylation holds diagnostic biomarker potential in patients with early colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/33078631 | http://purl.org/dc/terms/identifier | "doi:10.2217/epi-2020-0118"xsd:string |
| http://purl.uniprot.org/citations/33078631 | http://purl.uniprot.org/core/author | "Zidar N."xsd:string |
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| http://purl.uniprot.org/citations/33078631 | http://purl.uniprot.org/core/author | "Tomazic A."xsd:string |
| http://purl.uniprot.org/citations/33078631 | http://purl.uniprot.org/core/author | "Uhan S."xsd:string |
| http://purl.uniprot.org/citations/33078631 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33078631 | http://purl.uniprot.org/core/name | "Epigenomics"xsd:string |
| http://purl.uniprot.org/citations/33078631 | http://purl.uniprot.org/core/pages | "1677-1688"xsd:string |
| http://purl.uniprot.org/citations/33078631 | http://purl.uniprot.org/core/title | "Hypermethylated promoters of genes UNC5D and KCNA1 as potential novel diagnostic biomarkers in colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/33078631 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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