| http://purl.uniprot.org/citations/33080171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33080171 | http://www.w3.org/2000/01/rdf-schema#comment | "Conserved protein kinases with core cellular functions have been frequently redeployed during metazoan evolution to regulate specialized developmental processes. The Ser/Arg (SR)-rich splicing factor (SRSF) protein kinase (SRPK), which is implicated in splicing regulation, is one such conserved eukaryotic kinase. Surprisingly, we show that SRPK has acquired the capacity to control a neurodevelopmental ubiquitin signaling pathway. In mammalian embryonic stem cells and cultured neurons, SRPK phosphorylates Ser-Arg motifs in RNF12/RLIM, a key developmental E3 ubiquitin ligase that is mutated in an intellectual disability syndrome. Processive phosphorylation by SRPK stimulates RNF12-dependent ubiquitylation of nuclear transcription factor substrates, thereby acting to restrain a neural gene expression program that is aberrantly expressed in intellectual disability. SRPK family genes are also mutated in intellectual disability disorders, and patient-derived SRPK point mutations impair RNF12 phosphorylation. Our data reveal unappreciated functional diversification of SRPK to regulate ubiquitin signaling that ensures correct regulation of neurodevelopmental gene expression."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2020.09.025"xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Gourlay R."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Hastie C.J."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Toth R."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Moran J."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Cassidy A."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Varghese J."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Davidson L."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Macartney T.J."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Montecino M."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Bustos F."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Nardocci G."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Findlay G.M."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Brandenburg L."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Antico O."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Segarra-Fas A."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/author | "Soares R.F."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/pages | "629-647.e7"xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/title | "Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling."xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/33080171 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33080171 |