| http://purl.uniprot.org/citations/33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33081607 | http://www.w3.org/2000/01/rdf-schema#comment | "The coordination between mitochondrial and nuclear genes is crucial to eukaryotic organisms. Predicting the nature of these epistatic interactions can be difficult because of the transmission asymmetry of the genes involved. While autosomes and X-linked genes are transmitted through both sexes, genes on the Y chromosome and in the mitochondrial genome are uniparentally transmitted through males and females, respectively. Here, we generate 36 otherwise isogenic Drosophila melanogaster strains differing only in the geographical origin of their mitochondrial genome and Y chromosome, to experimentally examine the effects of the uniparentally inherited parts of the genome, as well as their interaction, in males. We assay longevity and gene expression through RNA-sequencing. We detect an important role for both mitochondrial and Y-linked genes, as well as extensive mitochondrial-Y chromosome epistasis. In particular, genes involved in male reproduction appear to be especially sensitive to such interactions, and variation on the Y chromosome is associated with differences in longevity. Despite these interactions, we find no evidence that the mitochondrial genome and Y chromosome are co-adapted within a geographical region. Overall, our study demonstrates a key role for the uniparentally inherited parts of the genome for male biology, but also that mito-nuclear interactions are complex and not easily predicted from simple transmission asymmetries."xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://purl.org/dc/terms/identifier | "doi:10.1098/rspb.2020.0469"xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://purl.uniprot.org/core/author | "Clark A.G."xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://purl.uniprot.org/core/author | "Agren J.A."xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://purl.uniprot.org/core/author | "Munasinghe M."xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33081607 | http://purl.uniprot.org/core/name | "Proc Biol Sci"xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://purl.uniprot.org/core/pages | "20200469"xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://purl.uniprot.org/core/title | "Mitochondrial-Y chromosome epistasis in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/33081607 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33081607 |
| http://purl.uniprot.org/citations/33081607 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHL1-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFB6-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6N2-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_E1JHJ2-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K801-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEE9-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KH81-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LH92-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JDD2-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6I6-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6J1-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |
| http://purl.uniprot.org/uniprot/#_A0A126GUS5-mappedCitation-33081607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33081607 |