| http://purl.uniprot.org/citations/33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33086056 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic mRNAs are 5' end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. Cap methyltransferase 1 (CMTR1) catalyzes 2'-O-ribose methylation of the first transcribed nucleotide (N1 2'-O-Me) to mask mRNAs from innate immune surveillance by retinoic-acid-inducible gene-I (RIG-I). Nevertheless, whether this modification regulates gene expression for neuronal functions remains unexplored. Here, we find that knockdown of CMTR1 impairs dendrite development independent of secretory cytokines and RIG-I signaling. Using transcriptomic analyses, we identify altered gene expression related to dendrite morphogenesis instead of RIG-I-activated interferon signaling, such as decreased calcium/calmodulin-dependent protein kinase 2α (Camk2α). In line with these molecular changes, dendritic complexity in CMTR1-insufficient neurons is rescued by ectopic expression of CaMK2α but not by inactivation of RIG-I signaling. We further generate brain-specific CMTR1-knockout mice to validate these findings in vivo. Our study reveals the indispensable role of CMTR1-catalyzed N1 2'-O-Me in gene regulation for brain development."xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.108269"xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/author | "Lin C.H."xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/author | "Huang Y.S."xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/author | "Lee Y.L."xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/author | "Kung F.C."xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/pages | "108269"xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/title | "CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2alpha Expression Independent of RIG-I Signaling."xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/33086056 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33086056 |
| http://purl.uniprot.org/citations/33086056 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33086056 |
| http://purl.uniprot.org/uniprot/#_D3Z7K9-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A1L0V6-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A7YY79-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EBV9-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGE1-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A2AP29-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EH87-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EHZ1-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EIE2-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EIG4-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4L303-mappedCitation-33086056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33086056 |