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http://purl.uniprot.org/citations/33099956http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Purpose

To clarify the biological function of long non-coding RNA (lncRNA) FLVCR1-AS1 in the progression of osteosarcoma.

Methods

The correlation between FLVCR1-AS1 level and pathological indexes of osteosarcoma patients was analyzed by chi-square test. Subsequently, the regulatory effects of FLVCR1-AS1 on the proliferative, migratory and invasive abilities of osteosarcoma cells were evaluated. Moreover, the relative levels of CTNNB1, SOX4, CCND1, CCND2 and MYC in osteosarcoma cells regulated by FLVCR1-AS1 were detected by qRT-PCR. Finally, rescue experiments were conducted to verify the role of wnt/β-catenin in osteosarcoma progression.

Results

LncRNA FLVCR1-AS1 was upregulated in osteosarcoma, which was positively correlated to tumor size, WHO grade and distant metastasis, but negatively correlated to survival of osteosarcoma patients. Overexpression of FLVCR1-AS1 markedly suppressed osteosarcoma cells to proliferate, migrate and invade. Relative levels of CTNNB1, SOX4, CCND1, CCND2, MYC and nucleus β-catenin were upregulated in U2OS and MG63 cells overexpressing FLVCR1-AS1. Finally, CTNNB1 knockdown was identified to reverse the influence of overexpressed FLVCR1-AS1 of osteosarcoma cells.

Conclusions

FLVCR1-AS1 accelerates the progression of osteosarcoma via activating wnt/β-catenin pathway."xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/author"Liu X."xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/author"Liang Y."xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/author"Jiang S."xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/author"Peng K."xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/author"Yuan C."xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/author"Kong P."xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/name"J BUON"xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/pages"2078-2085"xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/title"LncRNA FLVCR1-AS1 accelerates osteosarcoma cells to proliferate, migrate and invade via activating wnt/beta-catenin pathway."xsd:string
http://purl.uniprot.org/citations/33099956http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/33099956http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33099956
http://purl.uniprot.org/citations/33099956http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33099956
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http://purl.uniprot.org/uniprot/Q8TAF5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33099956