| http://purl.uniprot.org/citations/33103129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33103129 | http://www.w3.org/2000/01/rdf-schema#comment | "Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice. Spatial memory impairments observed in ghrelin-O-acyl transferase-null (GOAT-/-) mice that lack acyl-ghrelin (AG) but have high levels of UAG were rescued by acyl-ghrelin. Acyl-ghrelin-mediated neurogenesis in vitro was dependent on non-cell-autonomous BDNF signaling that was inhibited by UAG. These findings suggest that post-translational acylation of ghrelin is important to neurogenesis and memory in mice. To determine relevance in humans, we analyzed circulating AG:UAG in Parkinson disease (PD) patients diagnosed with dementia (PDD), cognitively intact PD patients, and controls. Notably, plasma AG:UAG was only reduced in PDD. Hippocampal ghrelin-receptor expression remained unchanged; however, GOAT+ cell number was reduced in PDD. We identify UAG as a regulator of hippocampal-dependent plasticity and spatial memory and AG:UAG as a putative circulating diagnostic biomarker of dementia."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.xcrm.2020.100120"xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Stark R."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Johnston F."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Sassi M."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Buntwal L."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Burn D.J."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Davies J.S."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Reichenbach A."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Wells T."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Andrews Z.B."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Roberts L.D."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Howell O."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Morgan A.H."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Siervo M."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Lockie S.H."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Santos V.V."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Mequinion M."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Hornsby A.K.E."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/author | "Carisi M.C."xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/name | "Cell Rep Med"xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/pages | "100120"xsd:string |
| http://purl.uniprot.org/citations/33103129 | http://purl.uniprot.org/core/title | "Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans."xsd:string |