| http://purl.uniprot.org/citations/33104252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33104252 | http://www.w3.org/2000/01/rdf-schema#comment | "The cathelin-related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation-associated carcinogenesis, and disrupted microbiome balance, as shown in systemic Cnlp-/- mice (also known as Camp-/- mice). However, the mechanistic basis for the role and the cellular source of CRAMP in colon pathophysiology are ill defined. This study, using either epithelial or myeloid conditional Cnlp-/- mice, demonstrated that epithelial cell-derived CRAMP played a major role in supporting normal development of colon crypts, mucus production, and repair of injured mucosa. On the other hand, myeloid cell-derived CRAMP potently supported colon epithelial resistance to bacterial invasion during acute inflammation with exacerbated mucosal damage and higher rate of mouse mortality. Therefore, a well concerted cooperation of epithelial- and myeloid-derived CRAMP is essential for colon mucosal homeostasis. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.org/dc/terms/identifier | "doi:10.1002/path.5572"xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Gong W."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Yoshimura T."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Trinchieri G."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Wang J.M."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Yao X."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "McCulloch J."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "O'hUigin C."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Bian X.W."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/author | "Dzutsev A.K."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/name | "J Pathol"xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/pages | "339-350"xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/title | "Distinct contributions of cathelin-related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis."xsd:string |
| http://purl.uniprot.org/citations/33104252 | http://purl.uniprot.org/core/volume | "253"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q3TZ97-mappedCitation-33104252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33104252 |