| http://purl.uniprot.org/citations/33105135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33105135 | http://www.w3.org/2000/01/rdf-schema#comment | "Syndecan-1 (Sdc-1) and glypican-1 (Gpc-1) are 2 important proteoglycans found in the glycocalyx and believed to govern transvascular distribution of fluid and protein. In this translational study, we assessed Sdc-1 and Gpc-1 knockout (KO) on whole body water balance after an intravenous volume challenge. Sdc-1 and Gpc-1 KO mice had higher starting blood water content versus strain-matched controls. Sdc-1 KO mice exhibited a significantly higher diuretic response (87%; p < 0.05), higher excreted volume/infusion volume ratio (p < 0.01), higher extravascular/infused ratio, and greater tissue water concentration (60 vs. 52%). Collectively, these suggest differences in kidney response and greater fluid efflux from peripheral vessels. The CD1 strain and Gpc-1 KO had a 2-3-fold larger urine output relative to C57 strain, but Gpc-1 KO reduced the excreted/infused ratio relative to controls (p < 0.01) and they maintained plasma dilution longer. Thus, genetic KO of Sdc-1 and Gpc-1 resulted in markedly different phenotypes. This work establishes the feasibility of performing fluid balance studies in mice."xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.org/dc/terms/identifier | "doi:10.1159/000510430"xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/author | "Patel M."xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/author | "Isbatan A."xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/author | "Hahn R.G."xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/author | "Dull R.O."xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/name | "J Vasc Res"xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/pages | "58-64"xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/title | "Syndecan-1 and Glypican-1 Knockout Alters Body Water Balance and Urine Response to Fluid Challenge in Mice."xsd:string |
| http://purl.uniprot.org/citations/33105135 | http://purl.uniprot.org/core/volume | "58"xsd:string |
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